Abstract
Aim of this study was have to known an effect of inhaled particulate matter 10 (PM10) of coal
dust on lipid profile, hematopoetic stem cells (HSC) and circulating endothelial cells (CECs)
in rats. A total of32 Wistar male rats, were randomly divided into four groups of 8 rats each,
including one control group and three groups for inhaled coal dust (concentration 6.25
mg/m3; 12.5 mg/m3; and 25 mg/m3). The exposure to coal dust exposure was conducted using
equipment that was designed by and available from Pharmacology Laboratory, Medical
Faculty, Brawijaya University of Malang. The level of total cholesterol was lower
significantly in rats inhaled to coal dust at compared with the control rats (p<0.05). The level
of triglycerydes was higher significantly in rats inhaled to coal dust at concentration 25
mg/m3 compared with the control rats (p<0.05). The level of LDL-c was lower significantly in
rats inhaled to coal dust at concentration 12.5 and 25 mg/m3 compared with the control rats
(p<0.05), but the level of HDL-c, HSCs and CECs were not different significantly (p>0.05).
The level of HDL-c/LDL-c ratio was higher significantly in rats inhaled to coal dust at
concentration 12.5 and 25 mg/m3 compared with the control rats (p<0.05). The level of
cholesterol/HDL-c ratio and atherogenic index were lower significantly in rats inhaled to
coal dust at concentration 12.5 and 25 mg/m3 compared with the control rats (p<0.05). The
level of hematopoetic stem cells and circulating endothelial cells were not different
significantly in rats inhaled to coal dust compared with the control rats (p>0.05).
Subchronic inhalation particulate matter 10 (PM10) coal dust have lowering effect on atherogenic
index due to decreasing cholesterol and LDL levels. Beside that, sub-chronic inhalation
particulate matter 10 (PM10) coal dust also have dyslipidemia which marked by increasing of
triglyceride levels.
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